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Network pharmacology analysis reveals HXTL mechanism in treating postmenopausal osteoporosis
2025-05-08 04:45:04| Spiritual Career Counseling
Download PDF Copy Reviewed Xia & He Publishing Inc.Apr 24 2025Background and objectivesHuo Xue Tong Luo Capsule (HXTL) has been clinically used to treat osteonecrosis of the femoral head, osteoporosis, and other bone and joint diseases with promising effects. Our previous study has shown that HXTL can promote osteogenesis in mesenchymal stem cells by inhibiting lncRNA-Miat expression through histone modifications. However, the mechanism by which HXTL treats postmenopausal osteoporosis (PMOP) remains unclear. In this study, we used network pharmacology-based mechanism prediction, molecular docking, and pharmacological validation to investigate the mechanism of HXTL in treating PMOP.MethodsThe key candidate targets and relevant signaling pathways of HXTL for PMOP treatment were predicted using network pharmacology and molecular docking analysis. RAW264.7 cells were used for Western blot to validate the predicted mechanistic pathways. The ovaries of mice were surgically removed to simulat...
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Apex court rules retired senators not entitled to pension increment tied to MP salary increases
2025-05-08 02:45:04| Spiritual Career Counseling
The Federal Court today overturned the decision in a pension dispute involving retired senators, ruling that they were not entitled to an increment in their pension when the salaries of serving Members of Parliament (MPs) are raised. Reuters file pic Planning your holiday getaway? Invest RM100 with Versa & grab RM10 FREE to kickstart your travel fund. Use VERSAMM10 now! Monday, 07 Apr 2025 7:58 PM MYT PUTRAJAYA, April 7 The Federal Court today overturned the decision in a pension dispute involving retired senators, ruling that they were not entitled to an increment in their pension when the salaries of serving Members of Parliament (MPs) are raised.A three-judge panel led by Chief Judge of Malaya Datuk Sri Hasnah Mohammed Hashim allowed the appeals by the Government of Malaysia, the Public Service Department (PSD) director-general and the chief administrator of Parliament.This decision reversed the Court of Appeals decision that had granted the claim of Datuk Idris Buang and Datuk...
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Doctors ordered to call off three-day strike in latest pay dispute
2025-05-08 02:45:04| Spiritual Career Counseling
AdvertisementNationalNSWHealthBy Angus ThomsonApril 1, 2025 5.07pm, registeror subscribeto save articles for later.Save articles for laterAdd articles to your saved list and come back to them any time.Thousands of doctors have been ordered to call off a planned three-day strike after the NSW government launched a last-minute court bid to prevent further mass disruption to the states public health system.NSW Health and the Australian Salaried Medical Officers Federation (ASMOF NSW) were called before the Industrial Relations Commission on Tuesday morning in an attempt to broker a deal after the doctors union rejected two insulting pay offers.The two parties could not agree on a final pay offer in the conciliation presided over by IRC Acting Justice Peter Kite.The commission instead ordered the union and its members to abandon the planned strike and refrain from taking industrial action for the next three months, a spokesman for NSW Health confirmed.The union must remove any refer...
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Employment