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New therapeutic frontiers in the management of achondroplasia
2025-04-26 19:45:03| Spiritual Career Counseling
Download PDF Copy Reviewed Compuscript LtdApr 20 2025A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the most common form of genetic dwarfism. This disorder stems primarily from gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene, which exerts widespread effects on skeletal development, leading to disrupted endochondral ossification, reduced chondrocyte proliferation, and abnormal bone formation.At the core of achondroplasia's pathology lies the hyperactivation of FGFR3, which impairs not only the growth of long bones but also affects cranial, spinal, and vertebral development. The article details how FGFR3 signaling suppresses critical pathways such as Indian hedgehog (IHH) and parathyroid hormone-related protein (PTHrP), and how its activation elevates cell cycle inhibitors, diminishes telomerase activity, and disrupts the...
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Employment
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Putin's deadly Easter missile raid targets cake factory and injures children
2025-04-26 18:45:03| Spiritual Career Counseling
To view this video please enable JavaScript, and consider upgrading to a webbrowser thatsupports HTML5videoUp NextVladimir Putins latest Easter onslaught on Ukraine included an attack on a cake factory.Further devastation hit the city of Sumy on Friday morning with an attack on a factory baking Easter treats that led to one person being killed and another injured,.The head of Sumy district state administration Mykhailo Melnyk said in an update on Facebook, Around 5 am, the enemy struck a UAV type Shahed on the pastry shop [in Sumy]. Damaged production of Easter cakes.The entrepreneur who came for the products was killed. An employee of a confectionery shop sought medical attention.The man was said to be collecting traditional paska sweet bread, a sweet treat popular at family gatherings in Ukraine.The attack on Sumy follows another strike on Palm Sunday that Ukrainian President Volodymyr Zelensky said was right in the heart of the city.It killed 34 people, including two child...
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Employment
Pollstar Awards: Taylor Swift, Stevie Nicks, Chappell Roan Take Home Top Awards
2025-04-26 18:45:03| Spiritual Career Counseling
Taylor Swift won the Major Tour of the Year award for the second year in a row at the 2025 Pollstar Awards in Beverly Hills on Wednesday night, while Stevie Nicks, Chappell Roan, Jelly Roll, Billie Eilish and Bruce Springsteen took home top awards as well.Nicks was inducted into the Pollstar Live Hall of Fame, alongside veteran concert promoters Barrie Marshall and Louis Messina, while Nashvilles famed Ryman Auditorium was inducted too. Chappell Roan won for New Headliner of the Year, Jelly Roll won for country tour of the year and Eilish beat out Swift for pop tour of the year. Dead and Companys high profile residency at the Sphere in Las Vegas unsurprisingly won for residency of the year. Related StoriesNewsJordan Firstman Is Sharing All Your 'Secrets'NewsJoel Katz, Longtime Music Industry Attorney, Dies at 80Pollstars awards show is one of the marquee events at the annual Pollstar Live conference, with the awards considered among the highest honors in the live music industry. Whi...
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Employment