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Potential targeted therapy for pediatric brain cancer identified by Dana-Farber team
2025-04-13 15:45:04| Spiritual Career Counseling
Boston An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma. They found that the drug, already FDA-approved for certain adult cancers, was generally safe and resulted in tumor reduction visible on brain scans, as well as clinical improvement, in 3 out of 7 patients.The study was published inCancer Cell.Pediatric-type high-grade gliomas are currently incurable brain tumors with median survival times less than 18 months after initial diagnosis.Avapritinib is a small molecule that crosses the blood-brain-barrier and targetsplatelet derived growth factor alpha (PDGFRA), which is overactive in some pediatric high-grade gliomas and leads to uncontrolled growth of cancer cells. The team is now designing a clinical trial of avapritinib treatment for newly diagnosed pediatric patients withPDGFRA-alt...
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Nick Grimshaw's super private fiancé he's yet to wed | HELLO!
2025-04-13 11:45:04| Spiritual Career Counseling
Nick Grimshaw is back with a new series of Bad Dog Academy, which sees trainers attempting to get the naughtiest dogs to start behaving.The presenter is the proud owner of his own two dogs, named Pig and Stinky Blob, whom he shares with his partner, choreographer and professional dancer Meshach 'Mesh' Henry. The couple have been engaged for over two years, with Mesh popping the question back in 2022, however, the duo have not yet made it down the aisle. InstagramHere's all you need to know about Mesh andNick'srelationship with the presenterWho is Mesh Henry?Mesh, 28, is a professional dancer and choreographer who trained at the London Contemporary Dance School and was a finalist in 2015's BBC Young Dancer. You may also likeInside Lauren Sánchez and Jeff Bezos' 'Princess Diana' style wedding of the centuryLady Eliza Spencer's 'special' destination wedding plans with boyfriend of 9 yearsWinnie Harlow's jaw-dropping 160,000 engagement ring is the dream for 2025 bridesThe star has work...
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Employment
The hidden cost of a privately funded Brisbane Arena
2025-04-13 11:45:04| Spiritual Career Counseling
PerspectiveNationalQueenslandBrisbane 2032 OlympicsBy Courtney KrukApril 2, 2025 7.41pm, registeror subscribeto save articles for later.Save articles for laterAdd articles to your saved list and come back to them any time.Of all the announcements to come out of the 100-day review into Olympic infrastructure, one I found surprising was the state governments decision not to include Brisbane Arena in plans for the 2032 Games.The reaction was muted, perhaps overshadowed by glossy renders of Victoria Park, or tempered by assurances from Premier David Crisafulli that we will still get a new indoor entertainment centre just a privately funded one in Woolloongabba.Some looked for a silver lining. Night-Life Economy Commissioner John JC Collins said it was disappointing that Brisbane Arena wasnt going ahead as first proposed, but the concept of a private-public partnership to develop the entertainment precinct at Woolloongabba is a great outcome.Crisafulli said he had already seen pri...
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Employment